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Renal Cell Carcinoma (RCC) DFP

DFP Profile

 

DFP NAME:

SAR Renal Cell Carcinoma (RCC) Disease Focused Panel (DFP)

 

DFP MISSION:

1. To advance the radiologic research contributions to the diagnosis and management of both localized and advanced renal cell carcinoma.

2. Create clinical practice and educational materials for healthcare personnel interested in imaging of renal cancer.

 

SAR RCC DFP MEMBERSHIP:

1. Hersh Chandarana, MD, Associate Professor; Departments of Radiology (New York University School of Medicine)

2. Matthew S. Davenport, MD, Assistant Professor, Radiology (University of Michigan)

3. Gary M. Israel, MD, Professor of Diagnostic Radiology (Yale School of Medicine)

4. John R. Leyendecker, MD, Professor of Radiology (University of Texas Southwestern
Medical Center)

5. Ivan Pedrosa, MD, Associate Professor, Radiology (University of Texas Southwestern
Medical Center)

6. Steven S. Raman, MD, Professor of Radiology, Urology & Surgery (UCLA Medical Center)

7. Erick M. Remer, MD FACR, Professor of Radiology (Cleveland Clinic)

8. Stuart G. Silverman, MD, Professor of Radiology (Brigham and Women’s Hospital/Harvard University) 

9. Andrew D. Smith, MD PhD, Associate Professor (University of Mississippi Medical Center)

10. Raghunandan Vikram, M.B.B.S., MRCP, FRCR, Associate Professor, Diagnostic Radiology (MD Anderson Cancer center)

11. Zhen J. Wang, MD, Associate Professor, Radiology (University of Califormia at San Francisco School of Medicine)


SAR RCC CONSULTANTS:

William Huang, MD, Associate Professor; Department of Urology (New York University School of Medicine)


SAR RCC LEADERSHIP:

Co-Chairs: Hersh Chandarana, MD & Stuart G. Silverman, MD

 

ONGOING PROJECTS (LEADS):

 

1. Develop Standardized Imaging Protocols for Evaluating Renal Masses and Renal Cancers (Zhen Wang, MD)

A.    The SAR RCC DFP believes that standardized imaging protocols will improve patient care, lead to efficient resource utilization, and provide data mining opportunities for multi-institutional research in renal mass and renal cancer imaging.

B.    Currently, substantial variations exist across institutions. In the past year, the Panel has developed a consensus around a set of standardized CT and MR imaging protocols that are based on clinical indications. These include examinations to evaluate indeterminate renal masses and others to assess advanced renal cancers.

C.    The standardized protocols will be made available on the SAR website.

D.    The Panel plans to survey SAR members to explore potential barriers in adopting and implementing standardized protocols.

2. Develop Structured Reporting in Management of Renal Cancer (Matthew Davenport, MD and Andrew Smith, MD, PhD)

A.    The SAR RCC DFP believes that standardized structured reports will improve patient care, lead to better communication among physician groups, and provide data mining opportunities for multi-institutional research in renal mass and renal cancer imaging.

B.    A survey of academic urologists and radiologists was undertaken to identify the key elements that would be included in a standard CT or MRI report of an indeterminate renal mass.

C.    Based on the survey data, a standardized reporting template will be developed and made available on the SAR website.

3. Comparison of Image Based Criteria for Assessment of Treatment Response in advanced RCC (Andrew Smith, MD, PhD and Erick Remer, MD)

A.    The SAR RCC DFP believes that quantitative imaging methods can serve as biomarkers and predict advanced renal cancer outcomes.

B.    The SAR RCC DFP formed a multi-institutional team under the leadership of Dr. Smith and submitted an National Institute of Health (NIH) U01grant proposal to optimize and validated a quantitative computed tomography imaging biomarker (vascular tumor burden) designed to predict metastatic disease response to anti-angiogenic therapy. The proposal largely focuses on assessing treatment response in patients with metastatic renal cell carcinoma. 

4. Develop a multi-institutional database / image repository (Raghu Vikram, MD, and Stuart Silverman)

A.    Under the auspices of the SAR DFP Oversight Committee progress is being made (including discussion with industry partners) to develop a data-base/image repository which will permit crowd-sourcing projects.



Member Resources 

Kidney Cancer Information for Patients: http://www.cancer.gov/types/kidney

Kidney Cancer Information for Health Providers: http://www.cancer.gov/types/kidney/hp

 

 

Recent relevant publications by SAR DFP Panel Members


2014:


Jinzaki M, Silverman SG, Akita H, Nagashima Y, Mikami S, Oya M. Renal angiomyolipoma: a radiological classification and update on recent developments in diagnosis and management. Abdominal Imaging 2014; 39:588-604.

 

Shinagare A, Silverman SG, Gershanik EF, Chang SL, Khorasani R. Evaluating hematuria: impact of guideline adherence on urologic cancer diagnosis. Am J Med 2014;127:625-632.

 

Maehara CK, Silverman SG, Lackson R, Khorasani R. Renal masses detected at CT: radiologists’ adherence to guidelines regarding management recommendations and communication of critical results. AJR 2014:203:828-834.


Sahni VA, Silverman SG. Imaging management of incidentally detected small renal masses. Seminars in Interventional Radiology 2014;31:9-19.


Allen BC, Tirman P, Jennings Clingan M, Manny J, Del Gaizo AJ, Leyendecker JR. Characterization of solid renal neoplasms with MRI in adults. Abdom Imaging. 2014; 39:358-87.


Childs DD, Clingan MJ, Zagoria RJ, Sirintrapun J, Tangtiang K, Anderson A, Leyendecker JR. In-phase signal intensity loss in solid renal masses on dual-echo gradient-echo MRI: association with malignancy and pathologic classification. AJR Am J Roentgenol. 2014; 203:W421-8.


Takagi T, Mir MC, Campbell RA, Sharma N, Remer EM, et al. Predictors of precision of excision and reconstruction in partial nephrectomy. J Urol 2014; 192:30-35.


Casalino DD, Remer EM, Bishoff JT, et al. ACR Appropriateness Criteria post-treatment follow-up of renal cell carcinoma. J Am Coll Radiol 2014;11:443-449.


Mir MC, Takagi T, Campbell RA, Sharma N, Remer EM, et al. Poorly Functioning Kidneys Recover from Ischemia after Partial Nephrectomy as Well as Strongly Functioning Kidneys. J Urol 2014:192:665-670.


Crouzet S, Chopra S, Tsai S, Kamoi K, Haber G-P, Remer EM, et al. Flank muscle volume changes after open and laparoscopic partial nephrectomy. J Endourol. 2014; 28:12021207.


Bhatt K, Remer EM, Goldfarb D. Renal Oncocytosis. J Urol 2014;192:1225-1226.


Ouzaid I, Autorino R, Fatica R, Herts BR, McLennan G, Remer EM, Haber GP. Active surveillance for renal angiomyolipoma: outcomes and factors predictive of delayed intervention. BJU Int. 2014;114:412-7.


Takagi T, Mir MC, Campbell RA, Sharma N, Remer EM, et al. Assessment of Outcomes in Partial Nephrectomy Incorporating Detailed Functional Analysis. Urology 2014; 84:1128-1133.


Takagi T, Mir MC, Sharma N, Remer EM, Li J, et al. Compensatory hypertrophy after partial and radical nephrectomy in adults. J Urol 2014;192:1612-8.


Kang SK, Huang WC, Pandharipande PV, Chandarana H. Solid renal masses: what the numbers tell us. AJR Am J Roentgenol. 2014; 202(6):1196-206.


Kierans AS*, Rusinek H, Lee A, Shaikh MB, Triolo M, Huang WC, Chandarana H. Textural Differences in Apparent Diffusion Coefficient Between Low and High Stage Clear Cell Renal Cell Cancer. AJR Am J Roentgenol. 2014; 203(6):W637-44.


Orton LP, Cohan RH, Davenport MS, Parker RA, Parameswaran A, Caoili EM, Kaza RK, Francis IR, Ellis JH, Wolf JS, Hafez K. Variability in computed tomography diameter measurements of solid renal masses. Abdom Imaging. 2014 Jun;39(3):533-42.


Caoili EM, Davenport MS. Role of percutaneous needle biopsy for renal masses.  Semin Intervent Radiol. 2014 Mar;31(1):20-6.


Patel J, Davenport MS, Khalatbari S, Cohan RH, Ellis JH, Platt JF. In vivo predictors of renal cyst pseudoenhancement at 120 kVp. AJR Am J Roentgenol. 2014 Feb;202(2):336-42.


Lee-Felker SA, Felker ER, Tan N, Margolis DJ, Young JR, Sayre J, Raman SSQualitative and quantitative MDCT features for differentiating clear cell renal cell carcinoma from other solid renal cortical masses. AJR Am J Roentgenol. 2014 Nov;203(5):W516-24.


Young JR, Margolis D, Sauk S, Pantuck AJ, Sayre J, Young JA, Hsu M, Raman SS. Clear cell renal cell carcinoma: multiphasic MDCT enhancement can predict the loss of chromosome 8p. Abdom Imaging. 2014 Jun;39(3):543-9.


McClure TD, Chow DS, Tan N, Sayre JA, Pantuck AJ, Raman SS.Intermediate outcomes and predictors of efficacy in the radiofrequency ablation of 100 pathologically proven renal cell carcinomas.J Vasc Interv Radiol. 2014 Nov;25(11):1682-8. 


 

2015:

 

Mullen KM, Sahni VA, Sadow CA, Silverman SG. Yield of urinary tract cancer diagnosis with repeat CT urography in patients with hematuria. AJR 2015;204:318-323.


Silverman SG, Israel GM, Trinh, Qouc-Dien. Incompletely characterized incidental renal masses: emerging data support conservative management. Radiology 2015;275:28-42.


Levesque VM, Shyn PB, Tuncali K, Tatli S, Nawfel RD, Olubiyi O, Silverman SG. Radiation dose during CT-guided percutaneous cryoablation of renal tumors: effects of a dose reduction protocol. European J Radiology 2015:84:2218-2221.


Sriram R, VanCiekinge M, Hansen A, Wang ZJ, Vigneron DB, Wilson DM, Keshari KR, Kurhanewicz J. Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor. NMR Biomed 2015;28(9):1141-1149.


Mir CM, Ercole C, Takagi T, Zhang Z, Velet L, Remer EM, et al. Decline in renal function after partial nephrectomy: Etiology and prevention. J Urol 2015;193:1889-1898. Jan 28. [Epub ahead of print].


Heilbrun ME, Remer EM, Casalino DD, et al. ACR Appropriateness Criteria® Indeterminate Renal Mass. J Am Coll Radiol 2015;12:333-341.


Zargar H, Samarasekera D, Khalifeh A, Remer EM, et al. Laparoscopic versus Percutaneous Cryoablation for the Small Renal Mass: 15-year Experience at a Single Center. Urology 2015;85: 850-5.


Zhang ZL, Ercole CE, Remer EM, et al. Analysis of atrophy after clamped partial nephrectomy and potential impact of ischemia. Urology 2015 Jun; 85:1417-22. 2015.


Caputo PA, Ramirez D, Zargar H, Akca O, Silva HA, O’Malley C, Remer EM, Kaouk JH. Laparoscopic cryoablation for renal cell carcinoma: 100-month oncologic outcomes, a single institution experience. J Urol 2015;194: 892-6.

 

Sharma N, Zhang Z, Mir MC, Takagi T, Bullen J, Campbell SC, Remer EM. Comparison of two CT-based methods to estimated pre-and postoperative renal parenchymal volume and correlation with functional changes after partial nephrectomy. Urology, 2015: 86; 80-86.


Smith AD, Allen BC, Sanyal R, Carson JD, Zhang H, Williams JH, Collins C, Griswold M, Zhang X. Outcomes, complications and costs in the management of Bosniak cystic renal lesions. Am J Roentgenol. 2015; 204:W550-6.


Gaing B, Sigmund EE, Huang WC, Babb JS, Parikh NS, Stoffel D, Chandarana H. Subtype Differentiation of Renal Tumors Using Voxel-based Histogram Analysis of Intravoxel Incoherent Motion Parameters. Invest Radiol. 2015; 50(3):144-52.


Doshi A, Huang W, Donin N, Chandarana H. MRI Features of Renal Cell Carcinoma That Predict Favorable Clinicopathologic Outcome. AJR Am J Roentgenol 2015.


Kang SK, Zhang A, Pandharipande PV, Chandarana H, Braithwaite RS, Littenberg B. Diffusion Weighted Imaging for Renal Mass Characterization: Systematic Review and Meta-analysis of Diagnostic Test Performance. AJR Am J Roentgenol. 2015; 205(2):317-24.


Dickerson EC, Davenport MS, Liu PS. Spontaneous regression of primary renal cell carcinoma following image-guided percutaneous biopsy. Clin Imaging. 2015 May-Jun;39(3):520-4.

 

 

2016 & In Press:

 

Zhang Z, Zhao J, Velet L, Ercole CE, Remer EM, et al. Functional Recovery from Extended Warm Ischemia Associated with Partial Nephrectomy. Urology 2016;87:106-113.

 

Zhang Z, Zhao J, Dong W, Remer E, et al. Acute kidney injury after partial nephrectomy: Role of parenchymal mass reduction and ischemia and impact on subsequent functional recovery. Eur Urol 2016;69:745-752.

 

Vikram R, Beland MD, Blaufox MD, Moreno CC, Gore JL, Harvin HJ, Heilbrun ME, Liauw SL, Nguyen PL, Nikoladis P, Preminger GM, Purysko AS, Raman SS, Taffel MT, Wang ZJ, Weinfeld RM, Remer EM, et al. ACR Appropriateness Criteria Renal Cell Carcinoma Staging. J Am Coll Radiol 2016 [Epub ahead of print].


Shinagare AB, Vikram R, Jaffe C, Akin O, Kirby J, Huang E, Freymann J, Sainani N, Sadow CA, Bathala TK, Rubin D, Oto A, Heller MT, Surabhi VR, Katabathina V, Silverman SG. Radiogenomics of clear cell renal cell carcinoma: preliminary findings of the cancer genome atlas-renal cell carcinoma (TCGA-RCC) research group. Abdominal Imaging (in press).


Sriram R, VanCriekinge M, DeLos Santos J, Keshari KR, Wilson DM, Peehl D, Kurhanewicz J, Wang ZJ. Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance. Tomography (in press).


Doshi AM, Ream J, Kierans AS, Bilbily M, Rusinek H, Huang W, Chandarana H. Differentiation of papillary renal cell carcinoma subtypes on MRI using qualitative and quantitative analysis. AJR Am J Roentgenol. (in press).


Wake N, Chandarana H, Huang WC, Taneja SS, Rosenkrantz AB. Application of Anatomically Accurate, Patient-Specific 3D Printed Models from MRI Data in Urologic Oncology. Clinical Radiology. (in press).



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